Current cooperation

Prof. Franck Suzent - Institute of Organic and Analytical Chemistry, University of Orléans, Orléans, France
Scope of cooperation: design and synthesis of new fluorophores for hypoxia imaging (OPUS 17, NAWA PHC Polonium), functionalization of ligands to form Ru complexes with anticancer activity targeting hypoxia (OPUS 11)

• Nitro-Pyrazinotriazapentalene scaffolds- nitroreductase quantification and in vitro fluorescence imaging of hypoxia (2021)
• Nitroimidazole derivatives of polypyridyl ruthenium complexes: towards understanding their anticancer activity and mode of action (2017)
• 2-Nitroimidazole-ruthenium polypyridyl complex as a new conjugate for cancer treatment and visualization (2014)

Prof. Pilippe Gros - Université de Lorraine, CNRS, L2CM, Nancy, France
Scope of cooperation: functionalization of ligands to form Ru complexes with anticancer activity combining cytotoxic and antimetastatic properties (OPUS 11)

• Unexplored features of Ru(II) polypyridyl complexes - towards combined cytotoxic and antimetastatic activity (2020)
• New Ruthenium Compounds bearing Semicarbazone 2-Formylopyridine Moiety: Playing with Auxiliary Ligands for Tuning the Mechanism of Biological Activity (2017)

Dr Michał Łomzik - Department of Organic Chemistry, Faculty of Chemistry, University of Łódź
Scope of cooperation: synthesis of ligands for Ru complexes, NMR measurements and analysis (OPUS 11)

• Inhibition of Matrix Metalloproteinases and Cancer Cell Detachment by Ru(II) Polypyridyl Complexes Containing 4,7-Diphenyl-1,10-phenanthroline Ligands-New Candidates for Antimetastatic Agents (2021)
• New Ruthenium Compounds bearing Semicarbazone 2-Formylopyridine Moiety: Playing with Auxiliary Ligands for Tuning the Mechanism of Biological Activity (2017)

Dr. habil. Dorota Rutkowska-Żbik - Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Krakow, Poland
Scope of cooperation: applying quantum-chemical methods to model the properties of Ru complexes, theoretical modeling of catalytic activity of metalloporphyrins.

• Relevance of the electron transfer pathway in the photodynamic activity of Ru(II) polypyridyl complexes containing 4,7-diphenyl-1,10-phenanthroline ligands under normoxic and hypoxic conditions (2022)
• Mechanistic insight into peroxo-shunt formation of biomimetic models for compound II, Their reactivity toward organic substrates, and the influence of N-methylimidazole axial ligation (2014)

Dr Mani Ganeshpandian - Department of Chemistry, SRM Institute of Science and Technology,  Tamil Nadu, India
Scope of cooperation: design, synthesis, and characterization of new organometallic ruthenium compounds with natural-product-inspired ligands, design functionalized liposomes to encapsulate the Ru(II)-polypyridyl complexes (NAWA)

• Nanoencapsulation of Ru(p‑Cymene) Complexes Bearing Ginger-Based Natural Product into Liposomal Nanoformulation to Improve Its Cellular Uptake and Antiproliferative Activity (2022)

Prof. Małgorzata Lekka - Department of Biophysical Microstructures, Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland
Scope of cooperation: applying atomic force microscopy (AFM) for the characterization of mechanical properties of single cells

• Inhibition of metastasis by polypyridyl Ru(II) complexes through modification of cancer cell adhesion – in vitro functional and molecular studies (2022)