The quantification of hypoxia is of great importance since it can help improve the assessment of cancer stage and prognosis, as well as the prediction of treatment response.
The main goal of our work is to provide luminescent probes that in a relatively easy manner enable the distinguishment of hypoxic from normoxic cells (imaging, quantification). Entirely new types of sensors based on the conjugation of the triazapentalene scaffold with nitro(hetero)aromatic moieties designed in the group of Prof. Franck Suzenet (NAWA PHC Polonium) are comprehensively studied by us in the model and in vitro systems (OPUS 17).
- E. Janczy-Cempa, O. Mazuryk, D. Sirbu, N. Chopin, M. Żarnik, M. Zastawna, C. Colas, M.-A. Hiebel, F. Suzenet, M. Brindell “Nitro-Pyrazinotriazapentalene scaffolds- nitroreductase quantification and in vitro fluorescence imaging of hypoxia” Sensors & Actuators B Chem. 2021, 346, 130504.
In our in vitro studies on cancer cells, we also investigate how hypoxic conditions influence the cytotoxic, antimetastatic, and photodynamic activity of Ru polypyridyl complexes.
- O. Mazuryk, E. Janczy-Cempa, J. Łagosz, D. Rutkowska-Żbik, A. Machnicka, A. Krasowska, P. Pietrzyk, G. Stochel, M. Brindell “Relevance of the electron transfer pathway in the photodynamic activity of Ru(II) polypyridyl complexes containing 4,7-diphenyl-1,10-phenanthroline ligands under normoxic and hypoxic conditions” Dalton Trans. 2022, 51, 1888-1900.
- O. Mazuryk, M. Maciuszek, G. Stochel, F. Suzenet, M. Brindell “2-Nitroimidazole-ruthenium polypyridyl complex as a new conjugate for cancer treatment and visualization.” J. Inorg. Biochem. 2014, 134, 83-91.